An MAO Function and Its Side-Effects



Monoamine oxidase inhibitors, or MAOIs, are a course of medicine that was created in the 1950s. They’re fairly efficient in dealing with a panic attacks, clinical depression, and other anxiety conditions. They’re used less often than SSRIs and their antidepressants as a result of needed dietary safety measures and threats of unfavorable responses when blended with specific medicines.

Some common MAOIs include:

  • Emsam or selegiline)
  • Nardil or phenelzine
  • Marplan or isocarboxazid
  • Parnate tranylcypromine

Emsam is a transdermal patch that’s used once a day. This setting of administration might be less likely to cause the nutritional complications connected with an oral route of management.

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How MAOIs Function?

The mind has different kinds of chemicals, messengers or neurotransmitters, that work as interaction representatives between various mind cells. These chemical messengers are molecular materials that can impact mood, anxiousness, cravings, rest, temperature level, heart rate, fear, aggressiveness, as well as lots of other emotional as well as physical features. Monoamine oxidase, or MAO, is an enzyme that degrades or breaks down three neurotransmitters related to the state of mind and anxiety:

  • Serotonin: This neurotransmitter contributes to modulating anxiety, sleep, mood, cravings, as well as sexuality.
  • Norepinephrine: Likewise called noradrenaline, norepinephrine affects rest as well as awareness and is believed to be associated with the fight-or-flight stress reaction.
  • Dopamine: Besides affecting body movement, dopamine is also thought to be involved in motivation, support, benefit, and addictive habits. Lots of concepts of psychosis recommend that dopamine plays a role in psychotic signs and symptoms.

MAOIs reduce the MAO enzyme’s activity. Less MAO causes higher dopamine, norepinephrine, and serotonin levels in the mind. The advantages of these rises are enhanced state of mind and anti-anxiety effects.

Usual Adverse Effects of MAOIs

This checklist is not all-inclusive, as well as you might experience other side effects not pointed out here. You need to report all medication-related negative effects to your medical professional.

  • Confusion
  • Diarrhea
  • Insomnia/reduced sleep
  • Lightheadedness
  • Edema or water retention
  • Dry mouth
  • Hypertension or high blood pressure
  • Muscle spasms
  • Hypotension or low blood pressure
  • Nausea
  • Weakness
  • Sexual dysfunction
  • Weight gain

Tyramine-Induced Hypertension Situation

Tyramine is a compound found in lots of foods. This substance has an impact on blood pressure, as well as is managed by the enzyme of MAO. When the enzyme of MAO is hindered, for example, when you consume an MAOI, tyramine can get to dangerously high levels, resulting in serious hypertension.

While taking an MAOI, it will be required to avoid foods as well as drinks.